| Accession | TIGR01907 |
| Name | casE_Cse3 |
| Function | CRISPR-associated protein Cas6/Cse3/CasE, subtype I-E/ECOLI |
| Gene Symbol | cas6e |
| Trusted Cutoff | 45.20 |
| Domain Trusted Cutoff | 45.20 |
| Noise Cutoff | 40.50 |
| Domain Noise Cutoff | 40.50 |
| Isology Type | equivalog |
| HMM Length | 208 |
| Mainrole Category | Mobile and extrachromosomal element functions |
| Subrole Category | Other |
| Gene Ontology Term | GO:0003674: molecular_function molecular_function |
| | GO:0043571: maintenance of CRISPR repeat elements biological_process |
| Author | Haft DH |
| Entry Date | May 8 2003 4:30PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This HMM family, represented by CT1974 from Chlorobium tepidum, is found in the Ecoli subtype of CRISPR/Cas regions and is designated Cse3 (CRISPR/Cas Subtype Ecoli protein 3).
The representative of this family from Thermus thermophilus HB8 (TTHB192) has been crystallized [2] and found to have a structure consisting of two domains with opposing parallel beta-sheets known as a beta-sheet platform. This structure is similar to those found in the Sex-lethal protein and poly(A)-binding protein. This structure is consistent with an RNA-binding function. |
| References | DR URL http://www.tigr.org/tigr-scripts/CMR2/genome_property_def.spl?prop=2003
DR URL http://www.tigr.org/tigr-scripts/CMR2/genome_property_def.spl?prop=57302
RN [1]
RT A guild of 45 CRISPR-associated (Cas) protein families and multiple CRISPR/cas subtypes exist in prokaryotic genomes
RA Haft DH, Selengut JD, Mongodin EF, Nelsen KE
RL PLOS Comput. Biol. 1(6), e60-e69, 2005
RN [2]
RM PMID:18703739
RT Small CRISPR RNAs guide antiviral defense in prokaryotes.
RA Brouns SJ, Jore MM, Lundgren M, Westra ER, Slijkhuis RJ, Snijders AP, Dickman MJ, Makarova KS, Koonin EV, van der Oost J
RL Science. 2008 Aug 15;321(5891):960-4.
RN [3]
RM PMID: 16672237
RT Crystal structure of hypothetical protein TTHB192 from Thermus thermophilus HB8 reveals a new protein family with an RNA recognition motif-like domain.
RA Ebihara A, Yao M, Masui R, Tanaka I, Yokoyama S, Kuramitsu S
RL Protein Sci. 2006 Jun;15(6):1494-9. Epub 2006 May 2. |
| Genome Property | GenProp0315: CRISPR system, I-E/Ecoli subtype (HMM) |
| | GenProp0021: CRISPR region (HMM) |
