HMM Summary Page: TIGR01907

FunctionCRISPR-associated protein Cas6/Cse3/CasE, subtype I-E/ECOLI
Gene Symbolcas6e
Trusted Cutoff45.20
Domain Trusted Cutoff45.20
Noise Cutoff40.50
Domain Noise Cutoff40.50
Isology Typeequivalog
HMM Length208
Mainrole CategoryMobile and extrachromosomal element functions
Subrole CategoryOther
Gene Ontology TermGO:0003674: molecular_function molecular_function
GO:0043571: maintenance of CRISPR repeat elements biological_process
AuthorHaft DH
Entry DateMay 8 2003 4:30PM
Last ModifiedFeb 14 2011 3:27PM
CommentCRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This HMM family, represented by CT1974 from Chlorobium tepidum, is found in the Ecoli subtype of CRISPR/Cas regions and is designated Cse3 (CRISPR/Cas Subtype Ecoli protein 3). The representative of this family from Thermus thermophilus HB8 (TTHB192) has been crystallized [2] and found to have a structure consisting of two domains with opposing parallel beta-sheets known as a beta-sheet platform. This structure is similar to those found in the Sex-lethal protein and poly(A)-binding protein. This structure is consistent with an RNA-binding function.
ReferencesDR URL DR URL RN [1] RT A guild of 45 CRISPR-associated (Cas) protein families and multiple CRISPR/cas subtypes exist in prokaryotic genomes RA Haft DH, Selengut JD, Mongodin EF, Nelsen KE RL PLOS Comput. Biol. 1(6), e60-e69, 2005 RN [2] RM PMID:18703739 RT Small CRISPR RNAs guide antiviral defense in prokaryotes. RA Brouns SJ, Jore MM, Lundgren M, Westra ER, Slijkhuis RJ, Snijders AP, Dickman MJ, Makarova KS, Koonin EV, van der Oost J RL Science. 2008 Aug 15;321(5891):960-4. RN [3] RM PMID: 16672237 RT Crystal structure of hypothetical protein TTHB192 from Thermus thermophilus HB8 reveals a new protein family with an RNA recognition motif-like domain. RA Ebihara A, Yao M, Masui R, Tanaka I, Yokoyama S, Kuramitsu S RL Protein Sci. 2006 Jun;15(6):1494-9. Epub 2006 May 2.
Genome PropertyGenProp0315: CRISPR system, I-E/Ecoli subtype (HMM)
GenProp0021: CRISPR region (HMM)