HMM Summary Page: TIGR01902

FunctionN-acetyl-ornithine/N-acetyl-lysine deacetylase
Trusted Cutoff163.10
Domain Trusted Cutoff163.10
Noise Cutoff125.90
Domain Noise Cutoff125.90
Isology Typesubfamily
HMM Length340
AuthorSelengut J
Entry DateMay 2 2003 4:47PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis clade of mainly archaeal and related bacterial species contains two characterized enzymes, an deacetylase with specificity for both N-acetyl-ornithine and N-acetyl-lysine from Thermus [1] which is found within a lysine biosynthesis operon, and a fusion protein with acetyl-glutamate kinase (an enzyme of ornithine biosynthesis) from Lactobacillus. It is possible that all of the sequences within this clade have dual specificity, or that a mix of specificities have evolved within this clade.
ReferencesRN [1] RM PMID: 11852094 RT Characterization of a lysK gene as an argE homolog in Thermus thermophilus HB27. RA Miyazaki J, Kobashi N, Fujii T, Nishiyama M, Yamane H. RL FEBS Lett 2002 Feb 13;512(1-3):269-74 DR HAMAP; MF_01120; 11 of 11
Genome PropertyGenProp0118: ornithine biosynthesis from glutamate, acetylated branch (HMM)
GenProp0193: lysine biosynthesis via alpha-aminoadipate (AAA pathway) (HMM)