HMM Summary Page: TIGR01893

FunctionXaa-His dipeptidase
Gene SymbolpepD
Trusted Cutoff343.75
Domain Trusted Cutoff343.75
Noise Cutoff185.15
Domain Noise Cutoff185.15
Isology Typesubfamily
EC Number3.4.13.20
HMM Length478
Gene Ontology TermGO:0006508: proteolysis biological_process
GO:0008769: X-His dipeptidase activity molecular_function
AuthorSelengut J
Entry DateApr 29 2003 3:27PM
Last ModifiedFeb 22 2012 3:53PM
CommentThis model represents a clade of dipeptidase enzymes, many of which are specific for carnosine (beta-alanyl-histidine). This enzymes is found broadly in bacteria and at least one archaeon (Methanosarcina). In most species there is only one sequence hitting this model, while Bacteroides thetaiotaomicron, Chlorobium tepidum and Clostridium perfringens have two each and Fusobacterium nucleatum has three. These may indicate that there is a broader substrate range than just carnosine in these (and other) species. 8/19/03 GO terms added [SS]
ReferencesIUBMB name is Xaa-His dipeptidase [SS 3/1/05]