HMM Summary Page: TIGR01885

Functionornithine--oxo-acid transaminase
Gene SymbolrocD
Trusted Cutoff378.40
Domain Trusted Cutoff378.40
Noise Cutoff352.30
Domain Noise Cutoff352.30
Isology Typeequivalog
EC Number2.6.1.13
HMM Length402
Gene Ontology TermGO:0004587: ornithine-oxo-acid transaminase activity molecular_function
AuthorHaft DH, Sunshine J
Entry DateApr 22 2003 3:11PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM describes the final step in the biosynthesis of ornithine from glutamate via the non-acetylated pathway. Ornithine amino transferase takes L-glutamate 5-semialdehyde and makes it into ornithine, which is used in the urea cycle, as well as in the biosynthesis of arginine. This model includes low-GC bacteria and eukaryotic species. The genes from two species are annotated as putative acetylornithine aminotransferases - one from Porphyromonas gingivalis (OMNI|PG1271), and the other from Staphylococcus aureus (OMNI|SA0170). After homology searching using BLAST it was determined that these two sequences were most closely related to ornithine aminotransferases. This model's seed includes one characterized hit, from Bacillus subtilis (SP|P38021).
References DR HAMAP; MF_01107; 17 of 120