HMM Summary Page: TIGR01884

FunctionCRISPR locus-related DNA-binding protein
Trusted Cutoff60.20
Domain Trusted Cutoff60.20
Noise Cutoff42.05
Domain Noise Cutoff42.05
Isology Typesubfamily
HMM Length202
Mainrole CategoryRegulatory functions
Subrole CategoryDNA interactions
Gene Ontology TermGO:0043571: maintenance of CRISPR repeat elements biological_process
AuthorHaft DH
Entry DateApr 22 2003 1:23PM
Last ModifiedFeb 14 2011 3:27PM
CommentMost but not all examples of this family are associated with CRISPR loci, a combination of DNA repeats and characteristic proteins encoded near the repeat cluster. The C-terminal region of this protein is homologous to DNA-binding helix-turn-helix domains with predicted transcriptional regulatory activity.
ReferencesDR URL DR URL RN [1] RT A guild of 45 CRISPR-associated (Cas) protein families and multiple CRISPR/cas subtypes exist in prokaryotic genomes RA Haft DH, Selengut JD, Mongodin EF, Nelsen KE RL PLOS Comput. Biol. 1(6), e60-e69, 2005 RN [2] RM 11788711 RT A DNA repair system specific for thermophilic Archaea and bacteria predicted by genomic context analysis. RA Makarova KS, Aravind L, Grishin NV, Rogozin IB, Koonin EV. RL Nucleic Acids Res. 2002 Jan 15;30(2):482-96
Genome PropertyGenProp0319: CRISPR system, I-A/Apern subtype (HMM)
GenProp0021: CRISPR region (HMM)