| Accession | TIGR01877 |
| Name | cas_cas6 |
| Function | CRISPR-associated endoribonuclease Cas6 |
| Gene Symbol | cas6 |
| Trusted Cutoff | 58.65 |
| Domain Trusted Cutoff | 58.65 |
| Noise Cutoff | 31.95 |
| Domain Noise Cutoff | 31.95 |
| Isology Type | equivalog |
| EC Number | 3.1.-.- |
| HMM Length | 200 |
| Mainrole Category | Mobile and extrachromosomal element functions |
| Subrole Category | Other |
| Gene Ontology Term | GO:0004521: endoribonuclease activity molecular_function |
| | GO:0043571: maintenance of CRISPR repeat elements biological_process |
| Author | Haft DH, Sunshine J |
| Entry Date | Apr 11 2003 6:11PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This broadly distributed, highly divergent Cas family is now characterized as an endoribonuclease that generates guide RNAs for host defense against phage and other invaders. The family contains a C-terminal motif GXGXXXXXGXG, where the each X between two Gly is hydrophobic and the spacer XXXXX contains (usually) one Arg or Lys. The seed alignment for the current version of this model has gappy columns removed. Members of this protein family are found associated with several different CRISPR/cas system subtypes, and consequently we designate this family Cas6. |
| References | DR URL http://www.tigr.org/tigr-scripts/CMR2/genome_property_def.spl?prop=2003
RN [1]
RT A guild of 45 CRISPR-associated (Cas) protein families and multiple CRISPR/cas subtypes exist in prokaryotic genomes
RA Haft DH, Selengut JD, Mongodin EF, Nelsen KE
RL PLOS Comput. Biol. 1(6), e60-e69, 2005
RN [1]
RM PMID:19141480
RT Cas6 is an endoribonuclease that generates guide RNAs for invader defense in prokaryotes.
RA Carte J, Wang R, Li H, Terns RM, Terns MP
RL Genes Dev. 2008 Dec 15;22(24):3489-96. |
| Genome Property | GenProp0021: CRISPR region (HMM) |
| | GenProp0317: CRISPR system, I-B subtype, Tneap branch (HMM-CLUST) |
| | GenProp0319: CRISPR system, I-A/Apern subtype (HMM-CLUST) |
| | GenProp0320: CRISPR system, I-B subtype, Hmari branch (HMM-CLUST) |
| | GenProp0318: CRISPR system, III-A/Mtube subtype (HMM-CLUST) |
| | GenProp0768: CRISPR system, Pging subtype (HMM-CLUST) |
