HMM Summary Page: TIGR01877

FunctionCRISPR-associated endoribonuclease Cas6
Gene Symbolcas6
Trusted Cutoff58.65
Domain Trusted Cutoff58.65
Noise Cutoff31.95
Domain Noise Cutoff31.95
Isology Typeequivalog
EC Number3.1.-.-
HMM Length200
Mainrole CategoryMobile and extrachromosomal element functions
Subrole CategoryOther
Gene Ontology TermGO:0004521: endoribonuclease activity molecular_function
GO:0043571: maintenance of CRISPR repeat elements biological_process
AuthorHaft DH, Sunshine J
Entry DateApr 11 2003 6:11PM
Last ModifiedFeb 14 2011 3:27PM
CommentCRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This broadly distributed, highly divergent Cas family is now characterized as an endoribonuclease that generates guide RNAs for host defense against phage and other invaders. The family contains a C-terminal motif GXGXXXXXGXG, where the each X between two Gly is hydrophobic and the spacer XXXXX contains (usually) one Arg or Lys. The seed alignment for the current version of this model has gappy columns removed. Members of this protein family are found associated with several different CRISPR/cas system subtypes, and consequently we designate this family Cas6.
ReferencesDR URL RN [1] RT A guild of 45 CRISPR-associated (Cas) protein families and multiple CRISPR/cas subtypes exist in prokaryotic genomes RA Haft DH, Selengut JD, Mongodin EF, Nelsen KE RL PLOS Comput. Biol. 1(6), e60-e69, 2005 RN [1] RM PMID:19141480 RT Cas6 is an endoribonuclease that generates guide RNAs for invader defense in prokaryotes. RA Carte J, Wang R, Li H, Terns RM, Terns MP RL Genes Dev. 2008 Dec 15;22(24):3489-96.
Genome PropertyGenProp0021: CRISPR region (HMM)
GenProp0317: CRISPR system, I-B subtype, Tneap branch (HMM-CLUST)
GenProp0319: CRISPR system, I-A/Apern subtype (HMM-CLUST)
GenProp0320: CRISPR system, I-B subtype, Hmari branch (HMM-CLUST)
GenProp0318: CRISPR system, III-A/Mtube subtype (HMM-CLUST)
GenProp0768: CRISPR system, Pging subtype (HMM-CLUST)