HMM Summary Page: TIGR01875

FunctionCRISPR-associated autoregulator DevR family
Trusted Cutoff67.30
Domain Trusted Cutoff67.30
Noise Cutoff43.10
Domain Noise Cutoff43.10
Isology Typesubfamily
HMM Length240
Mainrole CategoryRegulatory functions
Subrole CategoryDNA interactions
Gene Ontology TermGO:0003674: molecular_function molecular_function
GO:0043571: maintenance of CRISPR repeat elements biological_process
AuthorHaft DH
Entry DateApr 10 2003 2:55PM
Last ModifiedFeb 14 2011 3:27PM
CommentCRISPR is a term for Clustered Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR associated) proteins. This HMM represents one such family, represented by MJ0381 of Methanococcus jannaschii. This family includes the DevR protein of Myxococcus xanthus, a protein whose expression appears to regulated through a number of means, including both location and autorepression; DevR mutants are incapable of fruiting body development.
ReferencesRM 7693658 RT devRS, an autoregulated and essential genetic locus for fruiting body development in Myxococcus xanthus. RA Thony-Meyer L, Kaiser D. RL J Bacteriol 1993 Nov;175(22):7450-62
Genome PropertyGenProp0922: CRISPR system, Myxan subtype (HMM-CLUST)