HMM Summary Page: TIGR01873
| Accession | TIGR01873 |
| Name | cas_CT1978 |
| Function | CRISPR-associated endoribonuclease Cas2, subtype I-E/ECOLI |
| Gene Symbol | cas2e |
| Trusted Cutoff | 33.15 |
| Domain Trusted Cutoff | 33.15 |
| Noise Cutoff | 27.15 |
| Domain Noise Cutoff | 27.15 |
| Isology Type | equivalog |
| HMM Length | 87 |
| Mainrole Category | Mobile and extrachromosomal element functions |
| Subrole Category | Other |
| Gene Ontology Term | GO:0004521: endoribonuclease activity molecular_function |
| GO:0043571: maintenance of CRISPR repeat elements biological_process | |
| Author | Haft DH |
| Entry Date | Apr 9 2003 1:36PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | CRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This HMM represents a minor branch of the Cas2 family of CRISPR-associated endonuclease, whereas most Cas2 proteins are modeled instead by TIGR01573. This form of Cas2 is characteristic for the Ecoli subtype of CRISPR/Cas locus. |
| References | RN [1] RM PMID:18482976 RT A novel family of sequence-specific endoribonucleases associated with the clustered regularly interspaced short palindromic repeats. RA Beloglazova N, Brown G, Zimmerman MD, Proudfoot M, Makarova KS, Kudritska M, Kochinyan S, Wang S, Chruszcz M, Minor W, Koonin EV, Edwards AM, Savchenko A, Yakunin AF RL J Biol Chem. 2008 Jul 18;283(29):20361-71. Epub 2008 May 15. RN [2] RT A guild of 45 CRISPR-associated (Cas) protein families and multiple CRISPR/cas subtypes exist in prokaryotic genomes RA Haft DH, Selengut JD, Mongodin EF, Nelsen KE RL PLOS Comput. Biol. 1(6), e60-e69, 2005 |
| Genome Property | GenProp0021: CRISPR region (HMM) |
| GenProp0315: CRISPR system, I-E/Ecoli subtype (HMM) |