HMM Summary Page: TIGR01873

FunctionCRISPR-associated endoribonuclease Cas2, subtype I-E/ECOLI
Gene Symbolcas2e
Trusted Cutoff33.15
Domain Trusted Cutoff33.15
Noise Cutoff27.15
Domain Noise Cutoff27.15
Isology Typeequivalog
HMM Length87
Mainrole CategoryMobile and extrachromosomal element functions
Subrole CategoryOther
Gene Ontology TermGO:0004521: endoribonuclease activity molecular_function
GO:0043571: maintenance of CRISPR repeat elements biological_process
AuthorHaft DH
Entry DateApr 9 2003 1:36PM
Last ModifiedFeb 14 2011 3:27PM
CommentCRISPR is a term for Clustered, Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR-Associated) proteins. This HMM represents a minor branch of the Cas2 family of CRISPR-associated endonuclease, whereas most Cas2 proteins are modeled instead by TIGR01573. This form of Cas2 is characteristic for the Ecoli subtype of CRISPR/Cas locus.
ReferencesRN [1] RM PMID:18482976 RT A novel family of sequence-specific endoribonucleases associated with the clustered regularly interspaced short palindromic repeats. RA Beloglazova N, Brown G, Zimmerman MD, Proudfoot M, Makarova KS, Kudritska M, Kochinyan S, Wang S, Chruszcz M, Minor W, Koonin EV, Edwards AM, Savchenko A, Yakunin AF RL J Biol Chem. 2008 Jul 18;283(29):20361-71. Epub 2008 May 15. RN [2] RT A guild of 45 CRISPR-associated (Cas) protein families and multiple CRISPR/cas subtypes exist in prokaryotic genomes RA Haft DH, Selengut JD, Mongodin EF, Nelsen KE RL PLOS Comput. Biol. 1(6), e60-e69, 2005
Genome PropertyGenProp0021: CRISPR region (HMM)
GenProp0315: CRISPR system, I-E/Ecoli subtype (HMM)