HMM Summary Page: TIGR01858

Functionclass II aldolase, tagatose bisphosphate family
Trusted Cutoff443.55
Domain Trusted Cutoff443.55
Noise Cutoff349.45
Domain Noise Cutoff349.45
Isology Typeequivalog
EC Number4.1.2.-
HMM Length282
AuthorHaft DH
Entry DateMar 25 2003 1:44PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM describes tagatose-1,6-bisphosphate aldolases, and perhaps other closely related class II aldolases. This tetrameric, Zn2+-dependent enzyme is related to the class II fructose bisphosphate aldolase; fructose 1,6-bisphosphate and tagatose 1,6 bisphosphate differ only in chirality at C4.
ReferencesRN [1] RM 11940603 RT Structure of tagatose-1,6-bisphosphate aldolase. Insight into chiral discrimination, mechanism, and specificity of class II aldolases. RA Hall DR, Bond CS, Leonard GA, Watt CI, Berry A, Hunter WN. RL J Biol Chem 2002 Jun 14;277(24):22018-24 RN [2] RM 10712619 RT Exploring substrate binding and discrimination in fructose1, 6-bisphosphate and tagatose 1,6-bisphosphate aldolases. RA Zgiby SM, Thomson GJ, Qamar S, Berry A. RL Eur J Biochem 2000 Mar;267(6):1858-68 DR HAMAP; MF_01294; 23 of 29