| Accession | TIGR01854 |
| Name | lipid_A_lpxH |
| Function | UDP-2,3-diacylglucosamine diphosphatase |
| Gene Symbol | lpxH |
| Trusted Cutoff | 190.35 |
| Domain Trusted Cutoff | 190.35 |
| Noise Cutoff | 94.55 |
| Domain Noise Cutoff | 94.55 |
| Isology Type | equivalog |
| EC Number | 3.6.1.54 |
| HMM Length | 231 |
| Mainrole Category | Cell envelope |
| Subrole Category | Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides |
| Gene Ontology Term | GO:0008758: UDP-2,3-diacylglucosamine hydrolase activity molecular_function |
| | GO:0009245: lipid A biosynthetic process biological_process |
| Author | Haft DH |
| Entry Date | Mar 17 2003 9:07AM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This HMM represents LpxH, UDP-2,3-diacylglucosamine hydrolase, and essential enzyme in E. coli that catalyzes the fourth step in lipid A biosynthesis. Note that Pseudomonas aeruginosa has both a member of this family that shares this function and a more distant homolog, designated LpxH2, that does not. Many species that produce lipid A lack an lpxH gene in this family; some of those species have an lpxH2 gene instead, although for which the function is unknown. |
| References | RM 12000771
RT Accumulation of the lipid A precursor UDP-2,3-diacylglucosamine in an Escherichia coli mutant lacking the lpxH gene.
RA Babinski KJ, Kanjilal SJ, Raetz CR.
RL J Biol Chem 2002 Jul 19;277(29):25947-56
DR HAMAP; MF_00575; 107 of 110 |
| Genome Property | GenProp0204: KDO(2)-lipid A (Re LPS) biosynthesis and delivery (HMM) |
