HMM Summary Page: TIGR01853

FunctionUDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase LpxD
Gene SymbollpxD
Trusted Cutoff242.50
Domain Trusted Cutoff242.50
Noise Cutoff112.45
Domain Noise Cutoff112.45
Isology Typeequivalog
EC Number2.3.1.191
HMM Length325
Mainrole CategoryCell envelope
Subrole CategoryBiosynthesis and degradation of surface polysaccharides and lipopolysaccharides
Gene Ontology TermGO:0009245: lipid A biosynthetic process biological_process
GO:0016410: N-acyltransferase activity molecular_function
AuthorHaft DH
Entry DateMar 14 2003 11:03AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM describes LpxD, an enzyme for the biosynthesis of lipid A, a component oflipopolysaccharide (LPS) in the outer membrane outer leaflet of most Gram-negative bacteria. Some differences are found between lipid A of different species. This protein represents the third step from UDP-N-acetyl-D-glucosamine. The group added at this step generally is 14:0(3-OH) (myristate) but may vary; in Aquifex it appears to be 16:0(3-OH) (palmitate).
ReferencesDR URL; RN [1] RM 10753930 RT Characterization of a novel lipid A containing D-galacturonic acid that replaces phosphate residues. The structure of the lipid A of the lipopolysaccharide from the hyperthermophilic bacterium Aquifex pyrophilus. RA Plotz BM, Lindner B, Stetter KO, Holst O RL J Biol Chem 2000 Apr 14;275(15):11222-8 DR HAMAP; MF_00523; 261 of 262
Genome PropertyGenProp0204: KDO(2)-lipid A (Re LPS) biosynthesis and delivery (HMM)