| Accession | TIGR01852 |
| Name | lipid_A_lpxA |
| Function | acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase |
| Gene Symbol | lpxA |
| Trusted Cutoff | 231.05 |
| Domain Trusted Cutoff | 231.05 |
| Noise Cutoff | 114.05 |
| Domain Noise Cutoff | 114.05 |
| Isology Type | equivalog |
| EC Number | 2.3.1.129 |
| HMM Length | 254 |
| Mainrole Category | Cell envelope |
| Subrole Category | Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides |
| Gene Ontology Term | GO:0008780: acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity molecular_function |
| | GO:0009245: lipid A biosynthetic process biological_process |
| Author | Haft DH |
| Entry Date | Mar 14 2003 10:30AM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This HMM describes LpxA, an enzyme for the biosynthesis of lipid A, a component oflipopolysaccharide (LPS) in the outer membrane outer leaflet of most Gram-negative bacteria. Some differences are found between lipid A of different species, but this protein represents the first step (from UDP-N-acetyl-D-glucosamine) and appears to be conserved in function. Proteins from this family contain many copies of the bacterial transferase hexapeptide repeat (PF00132). |
| References | DR URL; http://www.genome.ad.jp/dbget-bin/show_pathway?MAP00540+2.3.1.129
DR HAMAP; MF_00387; 175 of 177 |
| Genome Property | GenProp0204: KDO(2)-lipid A (Re LPS) biosynthesis and delivery (HMM) |
