HMM Summary Page: TIGR01849

Functionpolyhydroxyalkanoate depolymerase, intracellular
Gene SymbolphaZ
Trusted Cutoff300.75
Domain Trusted Cutoff300.75
Noise Cutoff86.50
Domain Noise Cutoff86.50
Isology Typesubfamily
EC Number3.1.1.-
HMM Length406
Mainrole CategoryFatty acid and phospholipid metabolism
Subrole CategoryDegradation
AuthorHaft DH
Entry DateMar 11 2003 12:48PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM represents an intracellular depolymerase for polyhydroxyalkanoate (PHA), a carbon and energy storing polyester that accumulates in granules in many bacterial species when carbon sources are abundant but other nutrients are limiting. This family is named for PHAs generally, rather than polyhydroxybutyrate (PHB) specificially as in Ralstonia eutropha H16, to avoid overcalling chemical specificity in other species. Note that this family lacks the classic GXSXG lipase motif and instead shows weak similarity to some
ReferencesRM 11114905 RT Cloning of an intracellular Poly[D(-)-3-Hydroxybutyrate] depolymerase gene from Ralstonia eutropha H16 and characterization of the gene product. RA Saegusa H, Shiraki M, Kanai C, Saito T. RL Bacteriol 2001 Jan;183(1):94-100
Genome PropertyGenProp0055: polyhydroxyalkanoic acids (HMM)