HMM Summary Page: TIGR01848

Functionpolyhydroxyalkanoate synthesis repressor PhaR
Gene SymbolphaR
Trusted Cutoff109.45
Domain Trusted Cutoff109.45
Noise Cutoff52.35
Domain Noise Cutoff52.35
Isology Typeequivalog
HMM Length107
Mainrole CategoryFatty acid and phospholipid metabolism
Subrole CategoryBiosynthesis
Gene Ontology TermGO:0006355: regulation of transcription, DNA-dependent biological_process
GO:0016564: transcription repressor activity molecular_function
AuthorHaft DH
Entry DateMar 10 2003 4:08PM
Last ModifiedFeb 14 2011 3:27PM
CommentPoly-B-hydroxyalkanoates are lipidlike carbon/energy storage polymers found in granular inclusions. PhaR is a regulatory protein found in general near other proteins associated with polyhydroxyalkanoate (PHA) granule biosynthesis and utilization. It is found to be a DNA-binding homotetramer that is also capable of binding short chain hydroxyalkanoic acids and PHA granules. PhaR may regulate the expression of itself, of the phasins that coat granules, and of enzymes that direct carbon flux into polymers stored in granules. The C-terminal region is poorly conserved in this family and is not part of this model.//GO terms added 12/6/04 [SS]
ReferencesRN [1] RM 12081972 RT A repressor protein, PhaR, regulates polyhydroxyalkanoate (PHA) synthesis via its direct interaction with PHA. RA Maehara A, Taguchi S, Nishiyama T, Yamane T, Doi Y. RL J Bacteriol 2002 Jul;184(14):3992-4002 RN [2] RM 11914361 RT AniA regulates reserve polymer accumulation and global protein expression in Rhizobium etli. RA Encarnacion S, del Carmen Vargas M, Dunn MF, Davalos A, Mendoza G, Mora Y, Mora J RL J Bacteriol 2002 Apr;184(8):2287-95
Genome PropertyGenProp0055: polyhydroxyalkanoic acids (HMM)