HMM Summary Page: TIGR01845

Functionefflux transporter, outer membrane factor (OMF) lipoprotein, NodT family
Trusted Cutoff210.05
Domain Trusted Cutoff210.05
Noise Cutoff179.60
Domain Noise Cutoff179.60
Isology Typesubfamily
HMM Length460
Mainrole CategoryCellular processes
Subrole CategoryDetoxification
Gene Ontology TermGO:0006810: transport biological_process
GO:0009279: cell outer membrane cellular_component
GO:0015288: porin activity molecular_function
AuthorHaft DH
Entry DateMar 4 2003 4:26PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this HMM comprise a subfamily of the Outer Membrane Factor (TCDB 1.B.17) porins. OMF proteins operate in conjunction with a primary transporter of the RND, MFS, ABC, or PET systems, and a MFP (membrane fusion protein) to tranport substrates across membranes. The complex thus formed allows transport (export) of various solutes (heavy metal cations; drugs, oligosaccharides, proteins, etc.) across the two envelopes of the Gram-negative bacterial cell envelope in a single energy-coupled step. Current data suggest that the OMF (and not the MFP) is largely responsible for the formation of both the trans-outer membrane and trans-periplasmic channels. The roles played by the MFP have yet to be determined.