HMM Summary Page: TIGR01844

Functiontype I secretion outer membrane protein, TolC family
Trusted Cutoff225.15
Domain Trusted Cutoff225.15
Noise Cutoff183.80
Domain Noise Cutoff183.80
Isology Typesubfamily
HMM Length414
Mainrole CategoryProtein fate
Subrole CategoryProtein and peptide secretion and trafficking
Gene Ontology TermGO:0006810: transport biological_process
GO:0009279: cell outer membrane cellular_component
GO:0015288: porin activity molecular_function
AuthorHaft DH
Entry DateMar 4 2003 4:00PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this HMM are outer membrane proteins from the TolC subfamily within the RND (Resistance-Nodulation-cell Division) efflux systems. These proteins, unlike the NodT subfamily, appear not to be lipoproteins. All are believed to participate in type I protein secretion, an ABC transporter system for protein secretion without cleavage of a signal sequence, although they may, like TolC, participate also in the efflux of smaller molecules as well. This family includes the well-documented examples TolC (E. coli), PrtF (Erwinia), and AprF (Pseudomonas aeruginosa).
ReferencesRM 11589692 RT The role of the TolC family in protein transport and multidrug efflux. From stereochemical certainty to mechanistic hypothesis. RA Sharff A, Fanutti C, Shi J, Calladine C, Luisi B. RL Eur J Biochem 2001 Oct;268(19):5011-26
Genome PropertyGenProp0059: type I secretion (HMM)