HMM Summary Page: TIGR01843

Functiontype I secretion membrane fusion protein, HlyD family
Trusted Cutoff208.65
Domain Trusted Cutoff208.65
Noise Cutoff136.75
Domain Noise Cutoff136.75
Isology Typesubfamily
HMM Length422
Mainrole CategoryProtein fate
Subrole CategoryProtein and peptide secretion and trafficking
Gene Ontology TermGO:0008565: protein transporter activity molecular_function
GO:0030253: protein secretion by the type I secretion system biological_process
AuthorHaft DH
Entry DateMar 4 2003 10:58AM
Last ModifiedFeb 14 2011 3:27PM
CommentType I secretion is an ABC transport process that exports proteins, without cleavage of any signal sequence, from the cytosol to extracellular medium across both inner and outer membranes. The secretion signal is found in the C-terminus of the transported protein. This HMM represents the adaptor protein between the ATP-binding cassette (ABC) protein of the inner membrane and the outer membrane protein, and is called the membrane fusion protein. This model selects a subfamily closely related to HlyD; it is defined narrowly and excludes, for example, colicin V secretion protein CvaA and multidrug efflux proteins.
ReferencesDR URL;
Genome PropertyGenProp0059: type I secretion (HMM)