HMM Summary Page: TIGR01835

Functionhydroxymethylglutaryl-CoA synthase
Trusted Cutoff360.35
Domain Trusted Cutoff360.35
Noise Cutoff238.85
Domain Noise Cutoff238.85
Isology Typeequivalog
EC Number2.3.3.10
HMM Length382
Gene Ontology TermGO:0004421: hydroxymethylglutaryl-CoA synthase activity molecular_function
AuthorSelengut J
Entry DateFeb 25 2003 2:29PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis clade of hydroxymethylglutaryl-CoA (HMG-CoA) synthases is found in a limited spectrum of mostly gram-positive bacteria which make isopentenyl pyrophosphate (IPP) via the mevalonate pathway. This pathway is found primarily in eukaryotes and archaea, but the bacterial homologs are distinct, having aparrently diverged after being laterally transferred from an early eukaryote [1]. HMG-CoA synthase is the first step in the pathway and joins acetyl-CoA with acetoacetyl-CoA with the release of one molecule of CoA. The Borellia sequence may have resulted from a separate lateral transfer event.
ReferencesRN [1] RM PMID: 10894743 RT Identification, evolution, and essentiality of the mevalonate pathway for isopentenyl diphosphate biosynthesis in gram-positive cocci. RA Wilding EI, Brown JR, Bryant AP, Chalker AF, Holmes DJ, Ingraham KA, Iordanescu S, So CY, Rosenberg M, Gwynn MN. RL J Bacteriol 2000 Aug;182(15):4319-27
Genome PropertyGenProp0047: IPP biosynthesis via mevalonate (HMM)