HMM Summary Page: TIGR01829

Functionacetoacetyl-CoA reductase
Gene SymbolphbB
Trusted Cutoff302.10
Domain Trusted Cutoff302.10
Noise Cutoff300.90
Domain Noise Cutoff300.90
Isology Typesubfamily
EC Number1.1.1.36
HMM Length242
AuthorHaft DH
Entry DateFeb 24 2003 9:55AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM represent acetoacetyl-CoA reductase, a member of the family short-chain-alcohol dehydrogenases. Note that, despite the precision implied by the enzyme name, the reaction of EC is defined more generally as (R)-3-hydroxyacyl-CoA + NADP+ = 3-oxoacyl-CoA + NADPH. Members of this family may act in the biosynthesis of poly-beta-hydroxybutyrate (e.g. Rhizobium meliloti) and related poly-beta-hydroxyalkanoates. Note that the member of this family from Azospirillum brasilense, designated NodG, appears to lack acetoacetyl-CoA reductase activity and to act instead in the production of nodulation factor. This family is downgraded to subfamily for this NodG. Other proteins designated NodG, as from Rhizobium, belong to related but distinct protein families.
Genome PropertyGenProp0055: polyhydroxyalkanoic acids (HMM)