HMM Summary Page: TIGR01821

Function5-aminolevulinic acid synthase
Gene SymbolhemA
Trusted Cutoff338.55
Domain Trusted Cutoff338.55
Noise Cutoff334.75
Domain Noise Cutoff334.75
Isology Typeequivalog_domain
EC Number2.3.1.37
HMM Length402
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryHeme, porphyrin, and cobalamin
Gene Ontology TermGO:0003870: 5-aminolevulinate synthase activity molecular_function
GO:0006783: heme biosynthetic process biological_process
AuthorHaft DH
Entry DateFeb 19 2003 12:41AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM represents 5-aminolevulinic acid synthase, an enzyme for one of two routes to the heme precursor 5-aminolevulinate. The protein is a pyridoxal phosphate-dependent enzyme related to 2-amino-3-ketobutyrate CoA tranferase and 8-amino-7-oxononanoate synthase. This enzyme appears restricted to the alpha Proteobacteria and mitochondrial derivatives.
Genome PropertyGenProp0223: 5-aminolevulinate biosynthesis from succinyl-CoA and glycine (HMM)