HMM Summary Page: TIGR01805

Functionchorismate mutase
Trusted Cutoff71.20
Domain Trusted Cutoff71.20
Noise Cutoff61.20
Domain Noise Cutoff61.20
Isology Typeequivalog_domain
EC Number5.4.99.5
HMM Length81
Mainrole CategoryAmino acid biosynthesis
Subrole CategoryAromatic amino acid family
AuthorSelengut J
Entry DateJan 22 2003 3:14PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model represents a clade of chorismate mutase proteins/domains from gram positive species. The sequence from Enterococcus is fused to the C-terminus of an aparrent acetyltransferase, and the seuence from Clostridium acetobutylicum (but not perfringens) is fused to the N-terminus of shikimate-5-dehydrogenase, another enzyme of the chorismate pathway. All the other members of this clade are mono-functional. Members of this clade from Streptococcus and Lactococcus have been found which represent the sole chorismate mutase domain in their respective genomes which also exhibit evidence of the enzymes of both the upstream and downstream branches of the chorismate pathways.
Genome PropertyGenProp0039: phenylalanine biosynthesis from chorismate (HMM)
GenProp0045: tyrosine biosynthesis from chorismate (HMM)