HMM Summary Page: TIGR01801

Functionchorismate mutase
Gene SymbolaroA
Trusted Cutoff106.35
Domain Trusted Cutoff106.35
Noise Cutoff68.30
Domain Noise Cutoff68.30
Isology Typeequivalog_domain
EC Number5.4.99.5
HMM Length102
Mainrole CategoryAmino acid biosynthesis
Subrole CategoryAromatic amino acid family
AuthorSelengut J
Entry DateJan 22 2003 1:45PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model represents a small clade of chorismate mutase domains N-terminally fused to the first enzyme in the chorismate pathway, 2-dehydro-3-deoxyphosphoheptanoate aldolase (DAHP synthetase, AroA) which are found in some gram positive species and Deinococcus. Only in Deinococcus, where this domain is the sole CM domain in the genome can a trusted assignment of function be made. In the other species there is at least one other trusted CM domain present. The similarity between the Deinococcus gene and the others in this clade is sufficiently strong (~44% identity), that the whole clade can be trusted to be functional. The possibility exists, however, that in the gram positive species the fusion to the first enzyme in the pathway has evolved a separate, regulatory role.
Genome PropertyGenProp0039: phenylalanine biosynthesis from chorismate (HMM)
GenProp0045: tyrosine biosynthesis from chorismate (HMM)