| Accession | TIGR01800 |
| Name | cit_synth_II |
| Function | 2-methylcitrate synthase/citrate synthase II |
| Trusted Cutoff | 421.30 |
| Domain Trusted Cutoff | 421.30 |
| Noise Cutoff | 418.15 |
| Domain Noise Cutoff | 418.15 |
| Isology Type | subfamily |
| HMM Length | 368 |
| Author | Haft DH |
| Entry Date | Jan 22 2003 12:58PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | Members of this family are dimeric enzymes with activity as 2-methylcitrate synthase, citrate synthase, or both. Many Gram-negative species have a hexameric citrate synthase, termed citrate synthase I (TIGR01798). Members of this family (TIGR01800) appear as a second citrate synthase isozyme but typically are associated with propionate metabolism and synthesize 2-methylcitrate from propionyl-CoA; citrate synthase activity may be incidental. A number of species, including Thermoplasma acidophilum, Pyrococcus furiosus, and the Antarctic bacterium DS2-3R have a bifunctional member of this family as the only citrate synthase isozyme. |
| References | RM 9579066
RT Citrate synthase and 2-methylcitrate synthase: structural, functional and evolutionary relationships.
RA Gerike U, Hough DW, Russell NJ, Dyall-Smith ML, Danson MJ.
RL Microbiology 1998 Apr;144 ( Pt 4):929-35 |
| Genome Property | GenProp0033: TCA cycle (HMM) |
| | GenProp0240: propionyl-CoA catabolism via methylcitric acid (HMM) |
