HMM Summary Page: TIGR01800

Function2-methylcitrate synthase/citrate synthase II
Trusted Cutoff421.30
Domain Trusted Cutoff421.30
Noise Cutoff418.15
Domain Noise Cutoff418.15
Isology Typesubfamily
HMM Length368
AuthorHaft DH
Entry DateJan 22 2003 12:58PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this family are dimeric enzymes with activity as 2-methylcitrate synthase, citrate synthase, or both. Many Gram-negative species have a hexameric citrate synthase, termed citrate synthase I (TIGR01798). Members of this family (TIGR01800) appear as a second citrate synthase isozyme but typically are associated with propionate metabolism and synthesize 2-methylcitrate from propionyl-CoA; citrate synthase activity may be incidental. A number of species, including Thermoplasma acidophilum, Pyrococcus furiosus, and the Antarctic bacterium DS2-3R have a bifunctional member of this family as the only citrate synthase isozyme.
ReferencesRM 9579066 RT Citrate synthase and 2-methylcitrate synthase: structural, functional and evolutionary relationships. RA Gerike U, Hough DW, Russell NJ, Dyall-Smith ML, Danson MJ. RL Microbiology 1998 Apr;144 ( Pt 4):929-35
Genome PropertyGenProp0033: TCA cycle (HMM)
GenProp0240: propionyl-CoA catabolism via methylcitric acid (HMM)