HMM Summary Page: TIGR01798

Functioncitrate (Si)-synthase
Gene SymbolgltA
Trusted Cutoff485.15
Domain Trusted Cutoff485.15
Noise Cutoff465.10
Domain Noise Cutoff465.10
Isology Typeequivalog
EC Number2.3.3.1
HMM Length412
Mainrole CategoryEnergy metabolism
Subrole CategoryTCA cycle
Gene Ontology TermGO:0004108: citrate (Si)-synthase activity molecular_function
GO:0006099: tricarboxylic acid cycle biological_process
AuthorHaft DH
Entry DateJan 22 2003 11:18AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM describes one of several distinct but closely homologous classes of citrate synthase, the protein that brings carbon (from acetyl-CoA) into the TCA cycle. This form, class I, is known to be hexameric and allosterically inhibited by NADH in Escherichia coli, Acinetobacter anitratum, Azotobacter vinelandii, Pseudomonas aeruginosa, etc. In most species with a class I citrate synthase, a dimeric class II isozyme is found. The class II enzyme may act primarily on propionyl-CoA to make 2-methylcitrate or be bifunctional, may be found among propionate utilization enzymes, and may be constitutive or induced by propionate. Some members of this model group as class I enzymes, and may be hexameric, but have shown regulatory properties more like class II enzymes.
Genome PropertyGenProp0033: TCA cycle (HMM)