HMM Summary Page: TIGR01793

Functioncitrate (Si)-synthase, eukaryotic
Trusted Cutoff619.75
Domain Trusted Cutoff619.75
Noise Cutoff135.75
Domain Noise Cutoff135.75
Isology Typeequivalog
EC Number2.3.3.1
HMM Length427
Gene Ontology TermGO:0004108: citrate (Si)-synthase activity molecular_function
AuthorHaft DH
Entry DateJan 20 2003 9:39AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM includes both mitochondrial and peroxisomal forms of citrate synthase. Citrate synthase is the entry point to the TCA cycle from acetyl-CoA. Peroxisomal forms, such as SP:P08679 from yeast (recognized by the C-terminal targeting motif SKL) act in the glyoxylate cycle. Eukaryotic homologs excluded by the high trusted cutoff of this model include a Tetrahymena thermophila citrate synthase that doubles as a filament protein, a putative citrate synthase from Plasmodium falciparum (no TCA cycle), and a methylcitrate synthase from Aspergillus nidulans.
Genome PropertyGenProp0033: TCA cycle (HMM)