HMM Summary Page: TIGR01772

Functionmalate dehydrogenase, NAD-dependent
Gene Symbolmdh
Trusted Cutoff273.05
Domain Trusted Cutoff273.05
Noise Cutoff201.00
Domain Noise Cutoff201.00
Isology Typeequivalog
EC Number1.1.1.37
HMM Length313
Mainrole CategoryEnergy metabolism
Subrole CategoryTCA cycle
Gene Ontology TermGO:0006099: tricarboxylic acid cycle biological_process
GO:0030060: L-malate dehydrogenase activity molecular_function
AuthorSelengut J
Entry DateDec 18 2002 3:17PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model represents the NAD-dependent malate dehydrogenase found in eukaryotes and certain gamma proteobacteria. The enzyme is involved in the citric acid cycle as well as the glyoxalate cycle. Several isoforms exidt in eukaryotes. In S. cereviseae, for example, there are cytoplasmic, mitochondrial and peroxisomal forms. Although malate dehydrogenases have in some cases been mistaken for lactate dehydrogenases due to the similarity of these two substrates and the apparent ease with which evolution can toggle these activities, critical residues have been identified [1] which can discriminate between the two activities. At the time of the creation of this model no hits above the trusted cutoff contained critical residues typical of lactate dehydrogenases.
ReferencesRN [1] RM PMID: 11021970 RT Analysis and prediction of functional sub-types from protein sequence alignments. RA Hannenhalli SS, Russell RB. RL J. Mol Biol. 2000 Oct 13;303(1):61-76. DR HAMAP; MF_01516; 82 of 88
Genome PropertyGenProp0033: TCA cycle (HMM)
GenProp0755: pyruvate conversion to propionate, anaerobic, FAD/NAD-regenerating (HMM)