HMM Summary Page: TIGR01771

FunctionL-lactate dehydrogenase
Trusted Cutoff303.55
Domain Trusted Cutoff303.55
Noise Cutoff281.90
Domain Noise Cutoff281.90
Isology Typeequivalog
EC Number1.1.1.27
HMM Length299
Mainrole CategoryEnergy metabolism
Subrole CategoryAnaerobic
Gene Ontology TermGO:0004459: L-lactate dehydrogenase activity molecular_function
GO:0005737: cytoplasm cellular_component
GO:0019642: anaerobic glycolysis biological_process
AuthorSelengut J
Entry DateDec 18 2002 2:27PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model represents the NAD-dependent L-lactate dehydrogenases from bacteria and eukaryotes. This enzyme function as as the final step in anaerobic glycolysis. Although lactate dehydrogenases have in some cases been mistaken for malate dehydrogenases due to the similarity of these two substrates and the apparent ease with which evolution can toggle these activities, critical residues have been identified [1] which can discriminate between the two activities. At the time of the creation of this model no hits above the trusted cutoff contained critical residues typical of malate dehydrogenases.
ReferencesRN [1] RM PMID: 11021970 RT Analysis and prediction of functional sub-types from protein sequence alignments. RA Hannenhalli SS, Russell RB. RL J. Mol Biol. 2000 Oct 13;303(1):61-76. DR HAMAP; MF_00488; 171 of 173