HMM Summary Page: TIGR01769

Functionphosphoglycerol geranylgeranyltransferase
Trusted Cutoff161.55
Domain Trusted Cutoff161.55
Noise Cutoff85.85
Domain Noise Cutoff85.85
Isology Typeequivalog
EC Number2.5.1.41
HMM Length205
AuthorSelengut J
Entry DateDec 16 2002 3:59PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model represents geranylgeranylglyceryl phosphate synthase which catalyzes the first committed step in the synthesis of ether-linked membrane lipids in archaea [1]. The active enzyme is reported to be a homopentamer in Methanobacterium thermoautotrophicum but is reported to be a homodimer in Thermoplasma acidophilum.
ReferencesRN [1] RM PMID: 11732904 RT Geranylgeranylglyceryl phosphate synthase. Characterization of the recombinant enzyme from Methanobacterium thermoautotrophicum. RA Soderberg T, Chen A, Poulter CD. RL Biochemistry 2001 Dec 11;40(49):14847-54 RN [2] RM 12801917 RT Purification and characterization of geranylgeranylglyceryl phosphate synthase from a thermoacidophilic archaeon, Thermoplasma acidophilum. RA Nemoto N, Oshima T, Yamagishi A. RL J Biochem (Tokyo). 2003 May;133(5):651-7. DR HAMAP; MF_00112; 40 of 94