HMM Summary Page: TIGR01757

Functionmalate dehydrogenase, NADP-dependent
Trusted Cutoff598.30
Domain Trusted Cutoff598.30
Noise Cutoff424.30
Domain Noise Cutoff424.30
Isology Typeequivalog
EC Number1.1.1.82
HMM Length387
AuthorSelengut J
Entry DateDec 3 2002 10:20PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model represents the NADP-dependent malate dehydrogenase found in plants, mosses and green algae and localized to the chloroplast. Malate dehydrogenase converts oxaloacetate into malate, a critical step in the C4 cycle which allows circumvention of the effects of photorespiration. Malate is subsequenctly transported from the chloroplast to the cytoplasm (and then to the bundle sheath cells in C4 plants). The plant and moss enzymes are light regulated via cysteine disulfide bonds. The enzyme from Sorghum has been crystallized [1].
ReferencesRN [1] RM PMID: 10194350 RT Structural basis for light activation of a chloroplast enzyme: the structure of sorghum NADP-malate dehydrogenase in its oxidized form. RA Johansson K, Ramaswamy S, Saarinen M, Lemaire-Chamley M, Issakidis-Bourguet E, Miginiac-Maslow M, Eklund H. RL Biochemistry 1999 Apr 6;38(14):4319-26