HMM Summary Page: TIGR01751

Functioncrotonyl-CoA carboxylase/reductase
Gene SymbolccrA
Trusted Cutoff378.55
Domain Trusted Cutoff378.55
Noise Cutoff236.30
Domain Noise Cutoff236.30
Isology Typeequivalog
EC Number1.3.1.85
HMM Length398
AuthorSelengut J, Haft DH
Entry DateNov 22 2002 12:20PM
Last ModifiedMar 24 2014 10:43AM
CommentThe enzyme modelled by this HMM can convert crotonyl-CoA to butyryl-CoA (crotonyl-CoA reductase activity), but more importantly, in the presence of CO2, generates (2S)-ethylmalonyl-CoA. In serine cycle methylotrophic bacteria this enzyme is involved in the process of acetyl-CoA to glyoxylate [1,2]. In other bacteria the enzyme is used to produce extender units for incorporation into polyketides such as tylosin from Streptomyces fradiae [3] and coronatine from Pseudomonas syringae [4].
ReferencesRN [1] RM PMID: 8704985 RT Molecular characterization of a chromosomal region involved in the oxidation of acetyl-CoA to glyoxylate in the isocitrate-lyase-negative methylotroph Methylobacterium extorquens AM1. RA Chistoserdova LV, Lidstrom ME. RL Microbiology. 1996 Jun;142 ( Pt 6):1459-68. RN [2] RM PMID: 11872727 RT Glyoxylate regeneration pathway in the methylotroph Methylobacterium extorquens AM1. RA Korotkova N, Chistoserdova L, Kuksa V, Lidstrom ME. RL J Bacteriol. 2002 Mar;184(6):1750-8. RN [3] RM PMID: 9031628 RT Analysis of four tylosin biosynthetic genes from the tylLM region of the Streptomyces fradiae genome. RA Gandecha AR, Large SL, Cundliffe E. RL Gene 1997 Jan 15;184(2):197-203 RN [4] RM PMID: 9860992 RT Biosynthesis of the Pseudomonas polyketide coronafacic acid requires monofunctional and multifunctional polyketide synthase proteins. RA Rangaswamy V, Jiralerspong S, Parry R, Bender CL. RL Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15469-74. RN [5] RM PMID:22124767 RT Beyond ethylmalonyl-CoA: the functional role of crotonyl-CoA carboxylase/reductase homologs in expanding polyketide diversity. RA Wilson MC, Moore BS RL Nat Prod Rep. 2012 Jan;29(1):72-86.