HMM Summary Page: TIGR01750

Functionbeta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ
Gene SymbolfabZ
Trusted Cutoff155.15
Domain Trusted Cutoff155.15
Noise Cutoff125.15
Domain Noise Cutoff125.15
Isology Typeequivalog
EC Number4.2.1.-
HMM Length141
Mainrole CategoryFatty acid and phospholipid metabolism
Subrole CategoryBiosynthesis
Gene Ontology TermGO:0006633: fatty acid biosynthetic process biological_process
GO:0016836: hydro-lyase activity molecular_function
AuthorHaft DH
Entry DateNov 20 2002 4:35PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis enzyme, FabZ, shows overlapping substrate specificity with FabA with regard to chain length in fatty acid biosynthesis. FabZ works preferentially on shorter chains and is often designated (3R)-hydroxymyristoyl-[acyl carrier protein] dehydratase, although its actual specificity is broader. Unlike FabA, FabZ does not function as an isomerase and cannot initiate unsaturated fatty acid biosynthesis. However, only FabZ can act during the elongation of unsaturated fatty acid chains.
ReferencesRN [1] RM 8910376 RT Roles of the FabA and FabZ beta-hydroxyacyl-acyl carrier protein dehydratases in Escherichia coli fatty acid biosynthesis. RA Heath RJ, Rock CO. RL J Biol Chem 1996 Nov 1;271(44):27795-801 DR HAMAP; MF_00406; 410 of 423
Genome PropertyGenProp0681: fatty acid biosynthesis from acetyl-CoA (HMM)