| Accession | TIGR01750 |
| Name | fabZ |
| Function | beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ |
| Gene Symbol | fabZ |
| Trusted Cutoff | 155.15 |
| Domain Trusted Cutoff | 155.15 |
| Noise Cutoff | 125.15 |
| Domain Noise Cutoff | 125.15 |
| Isology Type | equivalog |
| EC Number | 4.2.1.- |
| HMM Length | 141 |
| Mainrole Category | Fatty acid and phospholipid metabolism |
| Subrole Category | Biosynthesis |
| Gene Ontology Term | GO:0006633: fatty acid biosynthetic process biological_process |
| | GO:0016836: hydro-lyase activity molecular_function |
| Author | Haft DH |
| Entry Date | Nov 20 2002 4:35PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This enzyme, FabZ, shows overlapping substrate specificity with FabA with regard to chain length in fatty acid biosynthesis. FabZ works preferentially on shorter chains and is often designated (3R)-hydroxymyristoyl-[acyl carrier protein] dehydratase, although its actual specificity is broader. Unlike FabA, FabZ does not function as an isomerase and cannot initiate unsaturated fatty acid biosynthesis. However, only FabZ can act during the elongation of unsaturated fatty acid chains. |
| References | RN [1]
RM 8910376
RT Roles of the FabA and FabZ beta-hydroxyacyl-acyl carrier protein dehydratases in Escherichia coli fatty acid biosynthesis.
RA Heath RJ, Rock CO.
RL J Biol Chem 1996 Nov 1;271(44):27795-801
DR HAMAP; MF_00406; 410 of 423 |
| Genome Property | GenProp0681: fatty acid biosynthesis from acetyl-CoA (HMM) |
