| Accession | TIGR01749 |
| Name | fabA |
| Function | beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabA |
| Gene Symbol | fabA |
| Trusted Cutoff | 238.15 |
| Domain Trusted Cutoff | 238.15 |
| Noise Cutoff | 160.10 |
| Domain Noise Cutoff | 160.10 |
| Isology Type | equivalog |
| EC Number | 4.2.1.59 |
| HMM Length | 169 |
| Mainrole Category | Fatty acid and phospholipid metabolism |
| Subrole Category | Biosynthesis |
| Author | Haft DH |
| Entry Date | Nov 20 2002 4:09PM |
| Last Modified | Dec 12 2011 10:26PM |
| Comment | This enzyme, FabA, shows overlapping substrate specificity with FabZ with regard to chain length in fatty acid biosynthesis. It is commonly designated 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.60) as if it were specific for that chain length, but its specificity is broader; it is active even in the initiation of fatty acid biosynthesis. This enzyme can also isomerize trans-2-decenoyl-ACP to cis-3-decenoyl-ACP to bypass reduction by FabI and instead allow biosynthesis of unsaturated fatty acids. FabA cannot elongate unsaturated fatty acids. |
| References | RN [1]
RM 8910376
RT Roles of the FabA and FabZ beta-hydroxyacyl-acyl carrier protein dehydratases in Escherichia coli fatty acid biosynthesis.
RA Heath RJ, Rock CO.
RL J Biol Chem 1996 Nov 1;271(44):27795-801
RN [2]
RM 9286984
RT Fatty acid biosynthesis in Pseudomonas aeruginosa: cloning and characterization of the fabAB operon encoding beta-hydroxyacyl-acyl carrier protein dehydratase (FabA) and beta-ketoacyl-acyl carrier protein synthase I (FabB).
RA Hoang TT, Schweizer HP.
RL J Bacteriol 1997 Sep;179(17):5326-32
DR HAMAP; MF_00405; 117 of 119 |
| Genome Property | GenProp0681: fatty acid biosynthesis from acetyl-CoA (HMM) |
