HMM Summary Page: TIGR01738

Functionpimelyl-[acyl-carrier protein] methyl ester esterase
Gene SymbolbioH
Trusted Cutoff206.95
Domain Trusted Cutoff206.95
Noise Cutoff120.40
Domain Noise Cutoff120.40
Isology Typeequivalog
EC Number3.1.1.85
HMM Length245
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryBiotin
Gene Ontology TermGO:0003824: catalytic activity molecular_function
GO:0009102: biotin biosynthetic process biological_process
AuthorHaft DH
Entry DateNov 7 2002 11:20AM
Last ModifiedDec 12 2011 10:52PM
CommentThis CoA-binding enzyme is required for the production of pimeloyl-coenzyme A, the substrate of the BioF protein early in the biosynthesis of biotin. Its exact function is unknown, but is proposed in ref 2. This enzyme belongs to the alpha/beta hydrolase fold family (Pfam HMM PF00561). Members of this family are restricted to the Proteobacteria.
ReferencesRN [1] RM 11904168 RT Purification and characterisation of the BIOH protein from the biotin biosynthetic pathway. RA Tomczyk NH, Nettleship JE, Baxter RL, Crichton HJ, Webster SP, Campopiano DJ. RN [2] RM 12732651 RT Integrating structure, bioinformatics, and enzymology to discover function: BioH, a new carboxylesterase from Escherichia coli. RA Sanishvili R, Yakunin AF, Laskowski RA, Skarina T, Evdokimova E, Doherty-Kirby A, Lajoie GA, Thornton JM, Arrowsmith CH, Savchenko A, Joachimiak A, Edwards AM. RL J Biol Chem. 2003 Jul 11;278(28):26039-45. DR HAMAP; MF_01260; 57 of 63
Genome PropertyGenProp0036: biotin biosynthesis (HMM)