HMM Summary Page: TIGR01738
| Accession | TIGR01738 |
| Name | bioH |
| Function | pimelyl-[acyl-carrier protein] methyl ester esterase |
| Gene Symbol | bioH |
| Trusted Cutoff | 206.95 |
| Domain Trusted Cutoff | 206.95 |
| Noise Cutoff | 120.40 |
| Domain Noise Cutoff | 120.40 |
| Isology Type | equivalog |
| EC Number | 3.1.1.85 |
| HMM Length | 245 |
| Mainrole Category | Biosynthesis of cofactors, prosthetic groups, and carriers |
| Subrole Category | Biotin |
| Gene Ontology Term | GO:0003824: catalytic activity molecular_function |
| GO:0009102: biotin biosynthetic process biological_process | |
| Author | Haft DH |
| Entry Date | Nov 7 2002 11:20AM |
| Last Modified | Dec 12 2011 10:52PM |
| Comment | This CoA-binding enzyme is required for the production of pimeloyl-coenzyme A, the substrate of the BioF protein early in the biosynthesis of biotin. Its exact function is unknown, but is proposed in ref 2. This enzyme belongs to the alpha/beta hydrolase fold family (Pfam HMM PF00561). Members of this family are restricted to the Proteobacteria. |
| References | RN [1] RM 11904168 RT Purification and characterisation of the BIOH protein from the biotin biosynthetic pathway. RA Tomczyk NH, Nettleship JE, Baxter RL, Crichton HJ, Webster SP, Campopiano DJ. RN [2] RM 12732651 RT Integrating structure, bioinformatics, and enzymology to discover function: BioH, a new carboxylesterase from Escherichia coli. RA Sanishvili R, Yakunin AF, Laskowski RA, Skarina T, Evdokimova E, Doherty-Kirby A, Lajoie GA, Thornton JM, Arrowsmith CH, Savchenko A, Joachimiak A, Edwards AM. RL J Biol Chem. 2003 Jul 11;278(28):26039-45. DR HAMAP; MF_01260; 57 of 63 |
| Genome Property | GenProp0036: biotin biosynthesis (HMM) |