HMM Summary Page: TIGR01736

Functionphosphoribosylformylglycinamidine synthase II
Gene SymbolpurL
Trusted Cutoff525.75
Domain Trusted Cutoff525.75
Noise Cutoff347.90
Domain Noise Cutoff347.90
Isology Typeequivalog
EC Number6.3.5.3
HMM Length718
Mainrole CategoryPurines, pyrimidines, nucleosides, and nucleotides
Subrole CategoryPurine ribonucleotide biosynthesis
Gene Ontology TermGO:0004642: phosphoribosylformylglycinamidine synthase activity molecular_function
GO:0009152: purine ribonucleotide biosynthetic process biological_process
AuthorHaft DH
Entry DateNov 6 2002 4:28PM
Last ModifiedFeb 14 2011 3:27PM
CommentPhosphoribosylformylglycinamidine synthase is a single, long polypeptide in most Proteobacteria and eukarotes. Three proteins are required in Bacillus subtilis and many other species. This is the longest of the three and is designated PurL, phosphoribosylformylglycinamidine synthase II, or FGAM synthase II.
ReferencesRM 2531746 RT The organization of the purL gene encoding 5'-phosphoribosylformylglycinamide amidotransferase of Escherichia coli RA Sampei G, Mizobuchi K. RL J Biol Chem 1989 Dec 15;264(35):21230-8 DR HAMAP; MF_00420; 218 of 219
Genome PropertyGenProp0110: purine (inosine-5'-phosphate) biosynthesis from ribose-5-phosphate (HMM)