HMM Summary Page: TIGR01735

Functionphosphoribosylformylglycinamidine synthase
Gene SymbolpurL
Trusted Cutoff1123.05
Domain Trusted Cutoff1123.05
Noise Cutoff634.50
Domain Noise Cutoff634.50
Isology Typeequivalog
EC Number6.3.5.3
HMM Length1307
Mainrole CategoryPurines, pyrimidines, nucleosides, and nucleotides
Subrole CategoryPurine ribonucleotide biosynthesis
Gene Ontology TermGO:0004642: phosphoribosylformylglycinamidine synthase activity molecular_function
GO:0006189: 'de novo' IMP biosynthetic process biological_process
AuthorHaft DH
Entry DateNov 6 2002 1:51PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM represents a single-molecule form of phosphoribosylformylglycinamidine synthase, also called FGAM synthase, an enzyme of purine de novo biosynthesis. This form is found mostly in eukaryotes and Proteobacteria. In Bacillus subtilis PurL (FGAM synthase II) and PurQ (FGAM synthase I), homologous to different parts of this model, perform the equivalent function; the unrelated small protein PurS is also required and may be a third subunit.
ReferencesRM 2531746 RT The organization of the purL gene encoding 5'-phosphoribosylformylglycinamide amidotransferase of Escherichia coli RA Sampei G, Mizobuchi K. RL J Biol Chem 1989 Dec 15;264(35):21230-8 DR HAMAP; MF_00419; 57 of 57
Genome PropertyGenProp0110: purine (inosine-5'-phosphate) biosynthesis from ribose-5-phosphate (HMM)
GenProp0110: purine (inosine-5'-phosphate) biosynthesis from ribose-5-phosphate (HMM)
GenProp0110: purine (inosine-5'-phosphate) biosynthesis from ribose-5-phosphate (HMM)