Accession | TIGR01735 |
Name | FGAM_synt |
Function | phosphoribosylformylglycinamidine synthase |
Gene Symbol | purL |
Trusted Cutoff | 1123.05 |
Domain Trusted Cutoff | 1123.05 |
Noise Cutoff | 634.50 |
Domain Noise Cutoff | 634.50 |
Isology Type | equivalog |
EC Number | 6.3.5.3 |
HMM Length | 1307 |
Mainrole Category | Purines, pyrimidines, nucleosides, and nucleotides |
Subrole Category | Purine ribonucleotide biosynthesis |
Gene Ontology Term | GO:0004642: phosphoribosylformylglycinamidine synthase activity molecular_function |
| GO:0006189: 'de novo' IMP biosynthetic process biological_process |
Author | Haft DH |
Entry Date | Nov 6 2002 1:51PM |
Last Modified | Feb 14 2011 3:27PM |
Comment | This HMM represents a single-molecule form of phosphoribosylformylglycinamidine synthase, also called FGAM synthase, an enzyme of purine de novo biosynthesis. This form is found mostly in eukaryotes and Proteobacteria. In Bacillus subtilis PurL (FGAM synthase II) and PurQ (FGAM synthase I), homologous to different parts of this model, perform the equivalent function; the unrelated small protein PurS is also required and may be a third subunit. |
References | RM 2531746
RT The organization of the purL gene encoding 5'-phosphoribosylformylglycinamide amidotransferase of Escherichia coli
RA Sampei G, Mizobuchi K.
RL J Biol Chem 1989 Dec 15;264(35):21230-8
DR HAMAP; MF_00419; 57 of 57 |
Genome Property | GenProp0110: purine (inosine-5'-phosphate) biosynthesis from ribose-5-phosphate (HMM) |
| GenProp0110: purine (inosine-5'-phosphate) biosynthesis from ribose-5-phosphate (HMM) |
| GenProp0110: purine (inosine-5'-phosphate) biosynthesis from ribose-5-phosphate (HMM) |