HMM Summary Page: TIGR01730

Functionefflux transporter, RND family, MFP subunit
Trusted Cutoff94.90
Domain Trusted Cutoff94.90
Noise Cutoff84.65
Domain Noise Cutoff84.65
Isology Typesubfamily
HMM Length322
Mainrole CategoryTransport and binding proteins
Subrole CategoryUnknown substrate
Gene Ontology TermGO:0005215: transporter activity molecular_function
GO:0006810: transport biological_process
AuthorHaft DH
Entry DateOct 23 2002 4:55PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM represents the MFP (membrane fusion protein) component of the RND family of transporters. RND refers to Resistance, Nodulation, and cell Division. It is, in part, a subfamily of PF00529 (Pfam release 7.5) but hits substantial numbers of proteins missed by that HMM. The related HlyD secretion protein, for which PF00529 is named, is outside the scope of this model. Attributed functions imply outward transport. These functions include nodulation, acriflavin resistance, heavy metal efflux, and multidrug resistance proteins. Most members of this family are found in Gram-negative bacteria. The proposed function of MFP proteins is to bring the inner and outer membranes together and enable transport to the outside of the outer membrane. Note, however, that a few members of this family are found in Gram-positive bacteria, where there is no outer membrane.
References DR HAMAP; MF_01544; 13 of 29