HMM Summary Page: TIGR01728

FunctionABC transporter, substrate-binding protein, aliphatic sulfonates family
Trusted Cutoff163.50
Domain Trusted Cutoff163.50
Noise Cutoff156.80
Domain Noise Cutoff156.80
Isology Typesubfamily
HMM Length290
Mainrole CategoryTransport and binding proteins
Subrole CategoryOther
Gene Ontology TermGO:0005488: binding molecular_function
GO:0009897: external side of plasma membrane cellular_component
GO:0030288: outer membrane-bounded periplasmic space cellular_component
GO:0042626: ATPase activity, coupled to transmembrane movement of substances molecular_function
GO:0042918: alkanesulfonate transport biological_process
GO:0043190: ATP-binding cassette (ABC) transporter complex cellular_component
AuthorHaft DH
Entry DateOct 22 2002 9:58AM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this family are substrate-binding periplasmic proteins of ABC transporters. This subfamily includes SsuA, a member of a transporter operon needed to obtain sulfur from aliphatic sulfonates. Related proteins outside the scope of this HMM include taurine (NH2-CH2-CH2-S03H) binding proteins, the probable sulfate ester binding protein AtsR, and the probable aromatic sulfonate binding protein AsfC. All these families make sulfur available when Cys and sulfate levels are low. Please note that phylogenetic analysis by neighbor-joining suggests that a number of sequences belonging to this family have been excluded because of scoring lower than taurine-binding proteins.
ReferencesRM 10506196 RT The Escherichia coli ssuEADCB gene cluster is required for the utilization of sulfur from aliphatic sulfonates and is regulated by the transcriptional activator Cbl. RA van Der Ploeg JR, Iwanicka-Nowicka R, Bykowski T, Hryniewicz MM, Leisinger T. RL J Biol Chem 1999 Oct 8;274(41):29358-65