HMM Summary Page: TIGR01719

Functionuridine phosphorylase
Trusted Cutoff249.95
Domain Trusted Cutoff249.95
Noise Cutoff125.50
Domain Noise Cutoff125.50
Isology Typeequivalog
EC Number2.4.2.3
HMM Length287
Mainrole CategoryPurines, pyrimidines, nucleosides, and nucleotides
Subrole CategorySalvage of nucleosides and nucleotides
Gene Ontology TermGO:0004731: purine-nucleoside phosphorylase activity molecular_function
GO:0006139: nucleobase-containing compound metabolic process biological_process
AuthorSelengut J
Entry DateOct 7 2002 11:04AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model represents a clade of mainly eucaryotic uridine phosphorylases. Genes from human [1] and mouse [2] have been characterized. This enzyme is a member of the PHP/UDP subfamily (PF01048) and is closely related to the bacterial uridine (TIGR01718) and inosine (TIGR00107) phosphorylase equivalogs. In addition to the eukaryotes, a gene from Mycobacterium leprae is included in this equivalog and may have resulted from lateral gene transfer.
ReferencesRN [1] RM PMID: 7488099 RT Cloning and expression of human uridine phosphorylase RA Watanabe S.-I., Uchida T. RL Biochem. Biophys. Res. Commun. 216:265-272(1995). RN [1] RM PMID: 7744869 RT Purification, cloning, and expression of murine uridine phosphorylase. RA Watanabe S.-I., Hino A., Wada K., Eliason J.F., Uchida T. RL J. Biol. Chem. 270:12191-12196(1995).