HMM Summary Page: TIGR01716

Functiontranscriptional activator, Rgg/GadR/MutR family, C-terminal domain
Trusted Cutoff36.90
Domain Trusted Cutoff36.90
Noise Cutoff35.35
Domain Noise Cutoff35.35
Isology Typesubfamily_domain
HMM Length220
Mainrole CategoryRegulatory functions
Subrole CategoryDNA interactions
Gene Ontology TermGO:0016563: transcription activator activity molecular_function
GO:0045941: positive regulation of transcription biological_process
AuthorHaft DH
Entry DateOct 4 2002 2:09PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM describes the whole, except for a 60 residue N-terminal helix-turn-helix DNA-binding domain (PFAM PF01381) of the family of proteins related to the transcriptional regulator Rgg, also called RopB. Rgg is required for secretion of several proteins, including a cysteine proteinase associated with virulence. GadR (GP|2352485) is a positive regulator of a glutamate-dependent acid resistance mechanism. MutR is a transcriptional activator for mutacin biosynthesis genes in Streptococcus mutans. This family appears restricted to the low-GC Gram-positive bacteria, including at least eight members in Lactococcus lactis.
ReferencesRN [1] RM 11159974 RN [2] RM 9484886