HMM Summary Page: TIGR01704

FunctionMTA/SAH nucleosidase
Gene SymbolmtnN
Trusted Cutoff73.80
Domain Trusted Cutoff73.80
Noise Cutoff58.20
Domain Noise Cutoff58.20
Isology Typeequivalog
EC Number3.2.2.16
HMM Length229
Mainrole CategoryCentral intermediary metabolism
Subrole CategoryOther
Gene Ontology TermGO:0008782: adenosylhomocysteine nucleosidase activity molecular_function
GO:0008930: methylthioadenosine nucleosidase activity molecular_function
GO:0019509: L-methionine salvage from methylthioadenosine biological_process
AuthorSelengut J
Entry DateSep 25 2002 5:15PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model represents the enzyme 5-methylthioadenosine/S-adenosylhomocysteine nucleosidase which acts on its two substrates at the same active site. This enzyme is involved in the recycling of the components of S-adenosylmethionine after it has donated one of its two non-ribose sulfur ligands to an acceptor. In the case of 5-methylthioadenosine this represents the first step of the methionine salvage pathway in bacteria [1,2,3]. This enzyme is widely distributed in bacteria, especially those that lack adenosylhomocysteinase (EC One clade of bacteria including Agrobacterium, Mesorhizobium, Sinorhizobium and Brucella includes sequences annotated as MTA/SAH nucleotidase, but differs significantly in homology and has no independent experimental evidence. There are homologs of this enzyme in plants, some of which score between trusted and noise cutoffs here, but there is no experimental evidence to validate this function at this time.
ReferencesRN [1] RM PMID: 10574451 RT Identification of yrrU as the methylthioadenosine nucleosidase gene in Bacillus subtilis. RA Sekowska A, Danchin A. RL DNA Res 1999 Oct 29;6(5):255-64 RN [2] RM PMID: 11591349 RT Structure of E. coli 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase reveals similarity to the purine nucleoside phosphorylases. RA Lee JE, Cornell KA, Riscoe MK, Howell PL. RL Structure (Camb) 2001 Oct;9(10):941-53 RN [3] RM PMID: 12022921 RT The methionine salvage pathway in Bacillus subtilis RA Sekowska A, Danchin, A. RL BMC Microbiology 2001; 2:8 DR HAMAP; MF_01684; 143 of 146
Genome PropertyGenProp0730: methylthioadenosine to methylthioribose-1-phosphate via MTR (HMM)
GenProp0757: quorum-sensing, autoinducer-2 system (HMM)