HMM Summary Page: TIGR01691

Function2,3-diketo-5-methylthio-1-phosphopentane phosphatase
Gene SymbolmtnC
Trusted Cutoff128.10
Domain Trusted Cutoff128.10
Noise Cutoff88.95
Domain Noise Cutoff88.95
Isology Typeequivalog
EC Number3.1.3.77
HMM Length224
Mainrole CategoryCentral intermediary metabolism
Subrole CategorySulfur metabolism
Gene Ontology TermGO:0016791: phosphatase activity molecular_function
GO:0016862: intramolecular oxidoreductase activity, interconverting keto- and enol-groups molecular_function
GO:0019509: L-methionine salvage from methylthioadenosine biological_process
AuthorSelengut J
Entry DateSep 23 2002 11:24AM
Last ModifiedDec 19 2011 12:58PM
CommentThis enzyme is the enolase-phosphatase of methionine salvage, a pathway that regenerates methionine from methylthioadenosine (MTA). Adenosylmethionine (AdoMet) is a donor of different moieties for various processes, including methylation reactions. Use of AdoMet for spermidine biosynthesis, which leads to polyamine biosynthesis, leaves MTA as a by-product that must be cleared. In Bacillus subtilis and related species, this single protein is replaced by separate enzymes with enolase and phosphatase activities.
ReferencesDR HAMAP; MF_01681; 84 of 89
Genome PropertyGenProp0729: methionine salvage from methylthioadenosine (HMM)