HMM Summary Page: TIGR01685

Functionmagnesium-dependent phosphatase-1
Gene SymbolMDP-1
Trusted Cutoff53.75
Domain Trusted Cutoff53.75
Noise Cutoff36.15
Domain Noise Cutoff36.15
Isology Typeequivalog
HMM Length174
AuthorSelengut J
Entry DateSep 19 2002 3:55PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model represents two closely related clades of sequences from eukaryotes and archaea. The mouse enzyme has been characterized as a phosphatase and has been positively identified as a member of the haloacid dehalogenase (HAD) superfamily by site-directed mutagenesis of the active site residues [1,2].
ReferencesRN [1] RM PMID: 11601995 RT MDP-1 is a new and distinct member of the haloacid dehalogenase family of aspartate-dependent phosphohydrolases. RA Selengut, JD RL Biochemistry 2001 Oct 23;40(42):12704-11 RN [2] RM PMID: 10889041 RT MDP-1: A novel eukaryotic magnesium-dependent phosphatase. RA Selengut JD, Levine RL. RL Biochemistry. 2000 Jul 18;39(28):8315-24.