HMM Summary Page: TIGR01683

Functionthiamine biosynthesis protein ThiS
Gene SymbolthiS
Trusted Cutoff37.45
Domain Trusted Cutoff37.45
Noise Cutoff29.40
Domain Noise Cutoff29.40
Isology Typeequivalog
HMM Length64
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryThiamine
Gene Ontology TermGO:0003824: catalytic activity molecular_function
GO:0009228: thiamine biosynthetic process biological_process
AuthorHaft DH
Entry DateSep 19 2002 3:21PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM represents ThiS, a small, ubiquitin-like thiamine biosynthesis protein related to MoaD, a molybdenum cofactor biosynthesis protein. Both proteins are involved in sulfur transfer. ThiS has a conserved Gly-Gly C-terminus that is modified, in reactions requiring ThiI, ThiF, IscS, and a sulfur atom from Cys, into the thiocarboxylate that provides the sulfur for thiazole biosynthesis.
ReferencesRM 10781607 RT The iscS gene in Escherichia coli is required for the biosynthesis of 4-thiouridine, thiamin, and NAD. RA Lauhon CT, Kambampati R. RL J Biol Chem. 2000 Jun 30;275(26):20096-103. DR HAMAP; MF_00443; 1 of 268
Genome PropertyGenProp0250: thiamine: hydroxyethylthiazole from 1-deoxy-D-xylulose-5-phosphate, cysteine, either Tyr or Gly (HMM)