Accession | TIGR01683 |
Name | thiS |
Function | thiamine biosynthesis protein ThiS |
Gene Symbol | thiS |
Trusted Cutoff | 37.45 |
Domain Trusted Cutoff | 37.45 |
Noise Cutoff | 29.40 |
Domain Noise Cutoff | 29.40 |
Isology Type | equivalog |
HMM Length | 64 |
Mainrole Category | Biosynthesis of cofactors, prosthetic groups, and carriers |
Subrole Category | Thiamine |
Gene Ontology Term | GO:0003824: catalytic activity molecular_function |
| GO:0009228: thiamine biosynthetic process biological_process |
Author | Haft DH |
Entry Date | Sep 19 2002 3:21PM |
Last Modified | Feb 14 2011 3:27PM |
Comment | This HMM represents ThiS, a small, ubiquitin-like thiamine biosynthesis protein related to MoaD, a molybdenum cofactor biosynthesis protein. Both proteins are involved in sulfur transfer. ThiS has a conserved Gly-Gly C-terminus that is modified, in reactions requiring ThiI, ThiF, IscS, and a sulfur atom from Cys, into the thiocarboxylate that provides the sulfur for thiazole biosynthesis. |
References | RM 10781607
RT The iscS gene in Escherichia coli is required for the biosynthesis of 4-thiouridine, thiamin, and NAD.
RA Lauhon CT, Kambampati R.
RL J Biol Chem. 2000 Jun 30;275(26):20096-103.
DR HAMAP; MF_00443; 1 of 268 |
Genome Property | GenProp0250: thiamine: hydroxyethylthiazole from 1-deoxy-D-xylulose-5-phosphate, cysteine, either Tyr or Gly (HMM) |