HMM Summary Page: TIGR01682

Functionmolybdopterin converting factor, subunit 1
Gene SymbolmoaD
Trusted Cutoff66.15
Domain Trusted Cutoff66.15
Noise Cutoff57.65
Domain Noise Cutoff57.65
Isology Typeequivalog
HMM Length80
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryMolybdopterin
Gene Ontology TermGO:0003824: catalytic activity molecular_function
GO:0006777: Mo-molybdopterin cofactor biosynthetic process biological_process
AuthorHaft DH
Entry DateSep 19 2002 3:14PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM describes MoaD. It excludes archaeal homologs, since many Archaea have two MoaD-like proteins, suggesting two different functions. The Pfam HMM PF02597 describes both the thiamine biosynthesis protein ThiS and this protein, MoaD, a subunit (together with MoaE, Pfam:PF02391) of the molybdopterin converting factor. Both ThiS and MoaD are involved in sulfur transfer reactions. Distribution of this family appears limited to species that also have a member of PF02391, but a number of Archaea have two different members, suggesting functionally distinct subtypes. The C-terminal Gly-Gly of this model is critical to function.
ReferencesDR EXPERIMENTAL; SP|P30748; Escherichia coli DR EXPERIMENTAL; SP|O96033; Homo sapiens
Genome PropertyGenProp0466: molybdopterin biosynthesis (HMM)