HMM Summary Page: TIGR01661

FunctionELAV/HuD family splicing factor
Trusted Cutoff279.10
Domain Trusted Cutoff279.10
Noise Cutoff212.05
Domain Noise Cutoff212.05
Isology Typesubfamily
HMM Length351
AuthorSelengut J
Entry DateSep 3 2002 9:28AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model describes the ELAV/HuD subfamily of splicing factors found in metazoa. HuD stands for the human paraneoplastic encephalomyelitis antigen D of which there are 4 variants in human [1]. ELAV stnds for the Drosophila Embryonic lethal abnormal visual protein [2]. ELAV-like splicing factors are also known in human as HuB (ELAV-like protein 2), HuC (ELAV-like protein 3, Paraneoplastic cerebellar degeneration-associated antigen) and HuR (ELAV-like protein 1). These genes are most closely related to the sex-lethal subfamily of splicing factors found in Dipteran insects (TIGR01659). These proteins contain 3 RNA-recognition motifs (rrm: PF00076).
ReferencesRN [1] RM PMID: 1655278 RT HuD, a Paraneoplastic Encephalomyelitis Antigen, Contains RNA-binding Domains and Is Homologous to Elav and Sex-lethal RA A. Szabo , J. Dalmau , G. Manley , M. Rosenfeld , E. Wong , J. Henson , J. B. Posner , and H. M. Furneaux RL Cell 67:325-333(1991). RN [2] RM PMID: 3144044 RT The elav gene product of Drosophila, required in neurons, has three RNP consensus motifs. RA Robinow S., Campos A.R., Yao K.-M., White K. RL Science 242:1570-1572(1988).