HMM Summary Page: TIGR01661
| Accession | TIGR01661 |
| Name | ELAV_HUD_SF |
| Function | ELAV/HuD family splicing factor |
| Trusted Cutoff | 279.10 |
| Domain Trusted Cutoff | 279.10 |
| Noise Cutoff | 212.05 |
| Domain Noise Cutoff | 212.05 |
| Isology Type | subfamily |
| HMM Length | 351 |
| Author | Selengut J |
| Entry Date | Sep 3 2002 9:28AM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This model describes the ELAV/HuD subfamily of splicing factors found in metazoa. HuD stands for the human paraneoplastic encephalomyelitis antigen D of which there are 4 variants in human [1]. ELAV stnds for the Drosophila Embryonic lethal abnormal visual protein [2]. ELAV-like splicing factors are also known in human as HuB (ELAV-like protein 2), HuC (ELAV-like protein 3, Paraneoplastic cerebellar degeneration-associated antigen) and HuR (ELAV-like protein 1). These genes are most closely related to the sex-lethal subfamily of splicing factors found in Dipteran insects (TIGR01659). These proteins contain 3 RNA-recognition motifs (rrm: PF00076). |
| References | RN [1] RM PMID: 1655278 RT HuD, a Paraneoplastic Encephalomyelitis Antigen, Contains RNA-binding Domains and Is Homologous to Elav and Sex-lethal RA A. Szabo , J. Dalmau , G. Manley , M. Rosenfeld , E. Wong , J. Henson , J. B. Posner , and H. M. Furneaux RL Cell 67:325-333(1991). RN [2] RM PMID: 3144044 RT The elav gene product of Drosophila, required in neurons, has three RNP consensus motifs. RA Robinow S., Campos A.R., Yao K.-M., White K. RL Science 242:1570-1572(1988). |