HMM Summary Page: TIGR01648

FunctionhnRNP-R, Q splicing factor family
Trusted Cutoff317.85
Domain Trusted Cutoff317.85
Noise Cutoff247.30
Domain Noise Cutoff247.30
Isology Typesubfamily
HMM Length577
AuthorSelengut J
Entry DateAug 28 2002 1:31PM
Last ModifiedFeb 14 2011 3:27PM
CommentSequences in this subfamily include the human heterogeneous nuclear ribonucleoproteins (hnRNP) R [1], Q [2] and APOBEC-1 complementation factor (aka APOBEC-1 stimulating protein)[3]. These proteins contain three RNA recognition domains (rrm: PF00076) and a somewhat variable C-terminal domain.
ReferencesRN [1] RM PMID: 9421497 RT Molecular definition of heterogeneous nuclear ribonucleoprotein R (hnRNP R) using autoimmune antibody: immunological relationship with hnRNP P RA W Hassfeld, EKL Chan, DA Mathison, D Portman, G Dreyfuss, G Steiner and EM Tan RL Nucleic Acids Research, Vol 26, Issue 2 439-445 RN [2] RM PMID: 11574476 RT SMN interacts with a novel family of hnRNP and spliceosomal proteins. RA Mourelatos Z, Abel L, Yong J, Kataoka N, Dreyfuss G. RL EMBO J 2001 Oct 1;20(19):5443-52 RN [3] RM PMID: 10781591 RT Purification and molecular cloning of a novel essential component of the apolipoprotein B mRNA editing enzyme-complex. RA Lellek H, Kirsten R, Diehl I, Apostel F, Buck F, Greeve J. RL J Biol Chem 2000 Jun 30;275(26):19848-56