HMM Summary Page: TIGR01645

Functionpoly-U binding splicing factor, half-pint family
Trusted Cutoff443.95
Domain Trusted Cutoff443.95
Noise Cutoff206.55
Domain Noise Cutoff206.55
Isology Typesubfamily
HMM Length607
AuthorSelengut J
Entry DateAug 27 2002 1:33PM
Last ModifiedFeb 14 2011 3:27PM
CommentThe proteins represented by this model contain three RNA recognition motifs (rrm: PF00076) and have been characterized as poly-pyrimidine tract binding proteins associated with RNA splicing factors [1,2,3]. In the case of PUF60 (GP|6176532), in complex with p54, and in the presence of U2AF, facilitates association of U2 snRNP with pre-mRNA [2].
ReferencesRN [1] RM PMID: 11879639 RT Half pint regulates alternative splice site selection in Drosophila. RA Van Buskirk C, Schupbach T. RL Dev Cell 2002 Mar;2(3):343-53 RN [2] RM PMID: 10606266 RT PUF60: a novel U2AF65-related splicing activity. RA Page-McCaw PS, Amonlirdviman K, Sharp PA. RL RNA 1999 Dec;5(12):1548-60 RN [3] RM PMID: 10668799 RT Interaction cloning and characterization of RoBPI, a novel protein binding to human Ro ribonucleoproteins. RA Bouffard P, Barbar E, Briere F, Boire G. RL RNA 2000 Jan;6(1):66-78