HMM Summary Page: TIGR01643

FunctionYD repeat (two copies)
Trusted Cutoff15.80
Domain Trusted Cutoff15.80
Noise Cutoff10.10
Domain Noise Cutoff10.10
Isology Typerepeat
HMM Length42
AuthorHaft DH
Entry DateAug 26 2002 5:31PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM describes two tandem copies of a 21-residue extracellular repeat found in Gram-negative, Gram-positive, and animal proteins. The repeat is named for a YD dipeptide, the most strongly conserved motif of the repeat. These repeats appear in general to be involved in binding carbohydrate; the chicken teneurin-1 YD-repeat region has been shown to bind heparin.
ReferencesRN [1] RM 10341219 RT Teneurin-1, a vertebrate homologue of the Drosophila pair-rule gene ten-m, is a neuronal protein with a novel type of heparin-binding domain. RA Minet AD, Rubin BP, Tucker RP, Baumgartner S, Chiquet-Ehrismann R. RL J Cell Sci 1999 Jun;112 ( Pt 12):2019-32 RN [2] RM 7934896 RT Rhs elements of Escherichia coli: a family of genetic composites each encoding a large mosaic protein. RA Hill CW, Sandt CH, Vlazny DA. RL Mol Microbiol 1994 Jun;12(6):865-71 RN [3] RM 2403547 RT Structure of the rhsA locus from Escherichia coli K-12 and comparison of rhsA with other members of the rhs multigene family. RA Feulner G, Gray JA, Kirschman JA, Lehner AF, Sadosky AB, Vlazny DA, Zhang J, Zhao S, Hill CW. RL J Bacteriol 1990 Jan;172(1):446-56