HMM Summary Page: TIGR01640

FunctionF-box protein interaction domain
Trusted Cutoff37.90
Domain Trusted Cutoff37.90
Noise Cutoff37.60
Domain Noise Cutoff37.60
Isology Typedomain
HMM Length232
AuthorHaft DH
Entry DateAug 23 2002 10:07AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM describes a large family of plant domains, with several hundred members in Arabidopsis thaliana. Most examples are found C-terminal to an F-box (PF00646), a 60 amino acid motif involved in ubiquitination of target proteins to mark them for degradation. Two-hybid experiments support the idea that most members are interchangeable F-box subunits of SCF E3 complexes. Some members have two copies of this domain.
ReferencesRM 12169662 RT The F-box subunit of the SCF E3 complex is encoded by a diverse superfamily of genes in Arabidopsis. RA Gagne JM, Downes BP, Shiu SH, Durski AM, Vierstra RD. RL Proc Natl Acad Sci U S A 2002 Aug 20;99(17):11519-11524