| Accession | TIGR01640 |
| Name | F_box_assoc_1 |
| Function | F-box protein interaction domain |
| Trusted Cutoff | 37.90 |
| Domain Trusted Cutoff | 37.90 |
| Noise Cutoff | 37.60 |
| Domain Noise Cutoff | 37.60 |
| Isology Type | domain |
| HMM Length | 232 |
| Author | Haft DH |
| Entry Date | Aug 23 2002 10:07AM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This HMM describes a large family of plant domains, with several hundred members in Arabidopsis thaliana. Most examples are found C-terminal to an F-box (PF00646), a 60 amino acid motif involved in ubiquitination of target proteins to mark them for degradation. Two-hybid experiments support the idea that most members are interchangeable F-box subunits of SCF E3 complexes. Some members have two copies of this domain. |
| References | RM 12169662
RT The F-box subunit of the SCF E3 complex is encoded by a diverse superfamily of genes in Arabidopsis.
RA Gagne JM, Downes BP, Shiu SH, Durski AM, Vierstra RD.
RL Proc Natl Acad Sci U S A 2002 Aug 20;99(17):11519-11524 |
