HMM Summary Page: TIGR01628

Functionpolyadenylate binding protein, human types 1, 2, 3, 4 family
Trusted Cutoff497.10
Domain Trusted Cutoff497.10
Noise Cutoff339.15
Domain Noise Cutoff339.15
Isology Typesubfamily
HMM Length595
AuthorSelengut J
Entry DateAug 9 2002 3:35PM
Last ModifiedFeb 14 2011 3:27PM
CommentThese eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: PF00076) followed by a PABP-specific domain (PF00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm [3]. There are four paralogs in Homo sapiens which are expressed in testis (GP:11610605_PABP3 [1]), platelets (SP:Q13310_PABP4 [2]), broadly expressed (SP:P11940_PABP1 [3]) and of unknown tissue range (SP:Q15097_PABP2).
ReferencesRN [1] RM PMID: 11328870 RT Human testis expresses a specific poly(A)-binding protein. RA Feral C, Guellaen G, Pawlak A. RL Nucleic Acids Res 2001 May 1;29(9):1872-1883 RN [2] RM PMID:8524242 RT iPABP, an inducible poly(A)-binding protein detected in activated human T cells. RA Yang H., Duckett C.S., Lindsten T. RL Mol. Cell. Biol. 15:6770-6776(1995). RN [3] RM PMID:9582337 RT The human poly(A)-binding protein 1 shuttles between the nucleus and the cytoplasm. RA Afonina E., Stauber R., Pavlakis G.N.